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Tocris Bioscience™ 2-APB
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Catalog No. 122410
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12-241-0 10 mg
12-245-0 50 mg
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Catalog No. 12-241-0 Supplier Tocris Bioscience™ Supplier No. 1224/10
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Description

IP3 receptor antagonist. Also TRP channel modulator

A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

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Chemical Identifiers

CAS 524-95-8
Molecular Formula C14H16BNO

Specifications

Quantity 10 mg
Formula Weight 225.1
Purity >98%
Molecular Weight (g/mol) 225.10
Chemical Name or Material 2-APB

Safety and Handling

Recommended Storage Store at Room Temperature
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