3,5-Dibromopyridine, 98+%

Description

CAS: 625-92-3 | C5H3Br2N | 236.89 g/mol

3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3′-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

Solubility
Soluble in Chloroform and Methanol. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, alkali metals, moisture.

Specifications

Chemical Identifiers

• CAS: 625-92-3
• Molecular Formula: C5H3Br2N
• Molecular Weight (g/mol): 236.89
• MDL Number: MFCD00014634
• InChI Key: SOSPMXMEOFGPIM-UHFFFAOYSA-N
• Synonym: pyridine, 3,5-dibromo, 3,5-dibromo-pyridine, 3,5-dibromo pyridine, 3,5-dibrompyridin, zlchem 300, 3.5-dibromopyridine, 3,5-dibromo-pyridin, pubchem2133, 3, 5-dibromopyridine, acmc-1auln
• PubChem CID: 69369
• ChEBI: CHEBI:51593
• IUPAC Name: 3,5-dibromopyridine
• SMILES: BrC1=CC(Br)=CN=C1

• Melting Point: 110°C to 113°C
• Quantity: 100 g
• Beilstein: 108477
• Solubility Information: Soluble in Chloroform and Methanol. Insoluble in water.
• Formula Weight: 236.9
• Percent Purity: ≥98%
• Chemical Name or Material: 3,5-Dibromopyridine

Safety and Handling

Hazard Category	H302+H312+H332-H315-H319-H335
Hazard Statement	GHS H Statement H301-H311-H332-H315-H319-H335 Toxic if swallowed. Toxic in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation	Hazard Class: 6.1; Packaging Group: III
EINECSNumber	210-916-4
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only