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3,5-Dibromopyridine, 98+%

Catalog No. AAA1087522
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Quantity:
5 g
25 g
100 g

CAS: 625-92-3 | C5H3Br2N | 236.89 g/mol

3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3′-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

Solubility
Soluble in Chloroform and Methanol. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, alkali metals, moisture.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 625-92-3
Molecular Formula C5H3Br2N
Molecular Weight (g/mol) 236.89
MDL Number MFCD00014634
InChI Key SOSPMXMEOFGPIM-UHFFFAOYSA-N
Synonym pyridine, 3,5-dibromo, 3,5-dibromo-pyridine, 3,5-dibromo pyridine, 3,5-dibrompyridin, zlchem 300, 3.5-dibromopyridine, 3,5-dibromo-pyridin, pubchem2133, 3, 5-dibromopyridine, acmc-1auln
PubChem CID 69369
ChEBI CHEBI:51593
IUPAC Name 3,5-dibromopyridine
SMILES BrC1=CC(Br)=CN=C1

Specifications

Melting Point 110°C to 113°C
Quantity 100 g
Beilstein 108477
Solubility Information Soluble in Chloroform and Methanol. Insoluble in water.
Formula Weight 236.9
Percent Purity ≥98%
Chemical Name or Material 3,5-Dibromopyridine
Hazard Category H302+H312+H332-H315-H319-H335
Hazard Statement GHS H Statement
H301-H311-H332-H315-H319-H335
Toxic if swallowed.
Toxic in contact with skin.
Harmful if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation Hazard Class: 6.1; Packaging Group: III
EINECSNumber 210-916-4
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only

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