Invitrogen™ 3-hydroxykynurenine Monoclonal Antibody (P3UI)

Catalog No.	Quantity
AMPA6616	100 μL

Catalog No. AMPA6616 Supplier Invitrogen™ Supplier No. MA116616

Description

Mouse Monoclonal Antibody

Suggested positive control: 3-OHKYN modified BSA.

3-Hydroxykynurenine (3-HK) is a metabolite in the kynurenine pathway of tryptophan catabolism, primarily involved in various physiological and pathological processes. It is a branch of the kynurenine monooxygenase (KMO) pathway and has been recognized for its dual role in the central nervous system. Structurally, 3-HK is an intermediate metabolite that undergoes autoxidation, which results in a range of products that may contribute to protein modification and cytotoxicity, especially in the context of oxidative stress. Although 3-HK has antioxidant and free radical scavenging properties, it is largely characterized as a toxic metabolite that can induce oxidative damage and cell death. The neuronal damage associated with 3-HK is mediated by free radicals rather than glutamate receptors. Altered levels of 3-HK have been observed in patients with various disorders, suggesting its potential involvement in neurodegenerative diseases. Research continues to explore the balance between its damaging and protective roles, with implications for therapeutic interventions targeting oxidative stress and neuroprotection.

Specifications

• Antigen: 3-hydroxykynurenine
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: P3UI
• Concentration: 2.6 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% sodium azide
• Gene Alias: C10H12N2O4
• Host Species: Mouse
• Immunogen: 3-OHKYN modified KLH.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Chemical
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ
• Target Molecule: Chemical