4-Nitrophenyl chloroformate, 97%

Description

CAS: 7693-46-1 | C7H4ClNO4 | 201.562 g/mol

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

Solubility
Soluble in acetone, chloroform, acetone, toluene and benzene.

Notes
Moisture sensitive. Store in a cool place. Incompatible with water, acids, alcohols, ammonia, amines and strong bases.

Specifications

Chemical Identifiers

• CAS: 7693-46-1
• Molecular Formula: C7H4ClNO4
• Molecular Weight (g/mol): 201.562
• MDL Number: MFCD00007321
• InChI Key: NXLNNXIXOYSCMB-UHFFFAOYSA-N
• Synonym: 4-nitrophenyl chloroformate, carbonochloridic acid, 4-nitrophenyl ester, chloroformic acid 4-nitrophenyl ester, p-nitrophenyl chloroformate, chloroformic acid p-nitrophenyl ester, 4-nitrophenyl carbonochloridate, formic acid, chloro-, p-nitrophenyl ester, 4-nitrophenylchlorocarbonat, 4-nitrophenyl choroformate
• PubChem CID: 82129
• IUPAC Name: (4-nitrophenyl) carbonochloridate
• SMILES: C1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl

• Melting Point: 75°C to 82°C
• Boiling Point: 159°C to 162°C (19 mmHg)
• Flash Point: >110°C (230°F)
• Odor: Acrid
• Quantity: 5 g
• UN Number: UN3261
• Beilstein: 518127
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in acetone,chloroform,acetone,toluene and benzene.
• Formula Weight: 201.57
• Percent Purity: 97%
• Chemical Name or Material: 4-Nitrophenyl chloroformate

Safety and Handling

Hazard Category	H301+H311+H331-H314-H335
Hazard Statement	GHS H Statement H301-H314-H318-H332 Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if inhaled.
Precautionary Statement	P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber	231-706-9
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only