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Tocris Bioscience™ 5-Amino-Thalidomide
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Catalog No. 7678100
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Quantity:
100 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Cereblon ligand with amine on C5 for onward chemistry

5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
CAS 191732-76-0
Quantity 100 mg
Target Degrader Building Blocks
Molecular Formula C13H11N3O4
Purity 0.95
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