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Tocris Bioscience™ 5-Ethynyl-2'-deoxyuridine
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Catalog No. 720750
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50 mg
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72-075-0 50 mg
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Catalog No. 72-075-0 Supplier Tocris Bioscience™ Supplier No. 7207/50
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Description

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

5-Ethynyl-2'-deoxyuridine is a thymidine analog for labeling DNA. Can be linked to an azide fluorophore through click chemistry and used to detect DNA synthesis in proliferating cells in vivo and in vitro. Detects very low levels of cell proliferation in tissues with low cellular turnover. 5-Ethynyl-2'-deoxyuridine suppresses cell proliferation in osteosarcoma and glioblastoma cell lines, induces a 'futile' DNA repair cycle and induces DNA strand breaks and apoptosis at a higher rate than Temozolomide (Cat. No. 2706).

Specifications

Chemical Name or Material 5-ethynyl-1-((2 R,4 S,5 R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1 H,3 H)-dione
CAS 61135-33-9
Quantity 50 mg
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C11H12N2O5
Purity 0.95
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