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MilliporeSigma™ 5-Hydroxymethylcytosine (5hmC), Mouse, Unlabeled, Clone: EDL HMC 1A,

Catalog No. MABE1093MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE1093MI 100 μg Unconjugated
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Catalog No. MABE1093MI Supplier MilliporeSigma™ Supplier No. MABE1093

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

5-Hydroxymethylcytosine (also known as 5-hmC) is the first oxidative product in the active demethylation of 5-methylcytosine (5mC). 5hmC is a DNA pyrimidine nitrogen base and is a predominantly stable DNA modification. It is produced by the action of three Ten-eleven translocation 1 (TET1) enzyme on 5mC. Each mammalian cell contains 5hmC, but its levels vary significantly depending on the cell type. Higher levels of 5hmC are found in neuronal cells and its level is shown to increase with age in hippocampus and cerebellum. It is also prevalent in embryonic stems cells and its reduced levels are shown to result in impaired self-renewal of stem cells. In the brain and in embryonic stem cells, 5hmC in enriched in promoters, gene bodies, and intergenic areas near genes and positively correlates with gene expression at these loci. 5hmC appears to play a role to promote gene expression during active demethylation. Significantly lower of 5hmC have been reported in cancer cell lines, melanoma, adenomas, and carcinomas compared to the normal surrounding tissue.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 5-Hydroxymethylcytosine (5hmC)
Applications Immunoprecipitation
Classification Monoclonal
Clone EDL HMC 1A
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Host Species Mouse
Immunogen BSA-conjugated 5-hydroxymethylcytidine.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Test Specificity Clone EDL HMC 1A targets 5-hydroxymethylcytosine (5hmC), but not 5-methylcytosine (5mC), 5-carboxylcytosine (5caC), 5-formylcytosine (5fC), or unmodified cytosine (C).
Target Species All species
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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