Invitrogen™ 5-hydroxymethylcytosine Monoclonal Antibody (DTA1002)

Catalog No.	Quantity
PIMA538433	100 μg

Catalog No. PIMA538433 Supplier Invitrogen™ Supplier No. MA538433

Description

Mouse Monoclonal Antibody

5-hydroxymethylcytosine Monoclonal Antibody for ELISA, DB, MeDIP

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.

Specifications

• Antigen: 5-hydroxymethylcytosine
• Applications: Dot Blot, ELISA, Methylated DNA Immunoprecipitation
• Classification: Monoclonal
• Clone: DTA1002
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene Alias: 5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2
• Host Species: Mouse
• Immunogen: 5-Hydroxymethylcytosine nucleotide.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Chemical
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ
• Target Molecule: Chemical