Invitrogen™ 5-Hydroxytryptophan Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119514

Catalog No. PIPA5119514

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

5-Hydroxytryptophan (5-HTP) is an intermediate metabolite in the biochemical synthesis of serotonin from the essential amino acid tryptophan. The conversion of tryptophan to 5-HTP involves the enzyme tryptophan hydroxylase (TPH), which exists in two isoforms: TPH1 and TPH2. TPH1 is mainly expressed in the peripheral tissues, while TPH2 is predominantly found in the central nervous system. Once synthesized, 5-HTP is further decarboxylated by aromatic L-amino acid decarboxylase (AADC) to produce serotonin (5-hydroxytryptamine, 5-HT). This biogenic amine plays a crucial role in regulating mood, cognition, and various physiological processes. Serotonin can also be acetylated and methylated to produce melatonin, a hormone involved in regulating sleep-wake cycles. Given its central role in serotonin biosynthesis, 5-HTP is often used in the treatment of conditions like depression, anxiety, and insomnia. Recent biotechnological advances have focused on optimizing the production of 5-HTP through engineered enzyme systems to meet increasing demand.

Specifications

• Antigen: 5-Hydroxytryptophan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: 5-HTP; oxitriptan
• Immunogen: 5-Hydroxytryptophan.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Target Molecule: Chemical

• Applications: Dot Blot, ELISA
• Concentration: 0.63 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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