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  6. 5-Methylcytosine (5-mC) Monoclonal Antibody (A1), Active Motif™ 

5-Methylcytosine (5-mC) Monoclonal Antibody (A1), Active Motif™
SDP

Catalog No. 501993433
Encompass
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100 μg
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50-199-3433 10 μg
50-199-3432 100 μg
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Catalog No. 50-199-3433 Supplier Active Motif Supplier No. 61480
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Description

Mouse Monoclonal Antibody

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.

Specifications

Antigen 5-Methylcytosine (5-mC)
Applications ChIP sequencing (ChIP-seq), Dot Blot, Immunoprecipitation
Classification Monoclonal
Clone A1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
Host Species Mouse
Immunogen This 5-Methylcytosine (5-mC) antibody was raised against 5-Methyl-cytidine conjugated to kLH and recognizes 5-Methylcytosine.
Purification Method Protein A
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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