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Invitrogen™ 5-Methylcytosine Polyclonal Antibody
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Catalog No. PA130675
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250 μg
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Catalog No. Quantity
PA130675 250 μg
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Catalog No. PA130675 Supplier Invitrogen™ Supplier No. PA130675
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Description

Sheep Polyclonal Antibody

The use of 7mM NaOH in the IP is crutial. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 5-Methylcytosine
Applications Dot Blot, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 3.2 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
Host Species Sheep
Immunogen 5-methyl Cytosine coupled to coupled to keyhole limpet hemocyanin (KLH).
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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