5-methylcytosine Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™

Mouse Recombinant Monoclonal Antibody

Supplier:  Active Motif 91187

Catalog No. 50-199-3731

Description

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.

Specifications

• Antigen: 5-methylcytosine
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Alias: 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
• Immunogen: This antibody was raised against 5-methylcytosine conjugated to kLH.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Dot Blot
• Concentration: 1 mg/mL
• Formulation: 140mM HEPES, 35mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical