Invitrogen™ 5-Methylcytosine Recombinant Rabbit Monoclonal Antibody (10S5V10)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542759

Catalog No. PIMA542759

Description

5-Methylcytosine Recombinant Monoclonal Antibody for ELISA, DB

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.

Specifications

• Antigen: 5-Methylcytosine
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Target Species: Chemical, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Dot Blot, ELISA
• Clone: 10S5V10
• Conjugate: Unconjugated
• Gene Alias: 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
• Immunogen: 5mC conjugated to KLH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical