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Invitrogen™ 53BP1 Polyclonal Antibody
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Catalog No. PIPA554565
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100 μL
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PIPA554565 100 μL
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Catalog No. PIPA554565 Supplier Invitrogen™ Supplier No. PA554565
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VPSPATRSEA LSSVLDQEEA MEIKEHHPEE GSSGSEVEEI PETPCESQGE ELKEENMESV PLHLSLTETQ SQGLCLQKEM PKKECSEAME VETSVISIDS PQKLA Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 53BP1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TP53BP1
Gene Accession No. P70399, Q12888
Gene Alias 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Gene Symbols TP53BP1, Trp53bp1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human 53BP1. Recombinant protein control fragment (Product #RP-89291).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27223, 296099, 7158
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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