Invitrogen™ 53BP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595093

Catalog No. PIPA595093

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human RT4 whole cell. IHC: Human Intestinal Cancer tissue, Rat Brain tissue, Mouse Brain tissue. ICC/IF: A549 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: 53BP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TP53BP1
• Gene Alias: 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27223, 296099, 7158
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: P70399, Q12888
• Gene Symbols: TP53BP1, Trp53bp1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human 53BP1 (1955-1972aa ERIGFKQHPKYKHDYVSH).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG