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Invitrogen™ 53BP1 Polyclonal Antibody, DyLight™ 650
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Catalog No. PIPA522753
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100 μL
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PIPA522753 100 μL
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Catalog No. PIPA522753 Supplier Invitrogen™ Supplier No. PA522753
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Description

Rabbit Polyclonal Antibody

Human has been tested in WB, IHC-P and ICC/IF, mouse and goat have only been tested in ICC/IF. Suggested positive control: U205, 293T, MO59K cell lysates and MEF lysates. Predicted cross-reactivity based on sequence identity: Chimpanzee/Gorilla/Orangutan (96%), Gibbon (94%), Marmoset (92%), Feline/Porcine/Rabbit/Sheep (90%).

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 53BP1
Applications ChIP Assay, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In Situ Hybridization (ISH), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.70 mg/mL
Conjugate DyLight 650
Formulation 50mM sodium borate with 0.05% sodium azide
Gene TP53BP1
Gene Accession No. P70399, Q12888
Gene Alias 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Gene Symbols TP53BP1, Trp53bp1
Host Species Rabbit
Immunogen Partial synthetic peptide made to an internal portion of human 53BP1 (between amino acids 350-400).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102182833, 27223, 296099, 478274, 509111, 7158
Target Species Human, Mouse, Rat, Canine, Monkey, Bovine, Fish, Goat, Bat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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