Invitrogen™ 53BP1 Polyclonal Antibody, HRP

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522793

Catalog No. PIPA522793

Description

This antibody reacts with Human samples in Western blot and ICC applications, and with Mouse in ICC applications. Predicted cross-reactivity based on sequence identity: Chimpanzee/Orangutan (99%), Gibbon/Gorilla (98%), Marmoset (95%).

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: 53BP1
• Classification: Polyclonal
• Conjugate: HRP
• Gene: TP53BP1
• Gene Alias: 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27223, 7158
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, In Situ Hybridization (ISH), Western Blot, Proximity Ligation Assay, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P70399, Q12888
• Gene Symbols: TP53BP1, Trp53bp1
• Immunogen: Synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12 and 19.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov