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Invitrogen™ 53BP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA116565
Description
Human has been tested in WB, IHC-P and ICC/IF, mouse and goat have only been tested in ICC/IF. Suggested positive control: U205, 293T, MO59K cell lysates and MEF lysates .
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Specifications
53BP1 | |
Polyclonal | |
Unconjugated | |
TP53BP1 | |
53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
102182833, 27223, 296099, 478274, 509111, 7158 | |
-20°C | |
Liquid |
ChIP Assay, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
P70399, Q12888 | |
TP53BP1, Trp53bp1 | |
The epitope recognized by this antibody maps to a region between residues 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158). | |
100 μL | |
Primary | |
Human, Mouse, Rat, Canine, Monkey, Bovine, Fish, Goat, Bat | |
Antibody | |
IgG |
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