Invitrogen™ 53BP1 Recombinant Rabbit Monoclonal Antibody (BL-250-1H11)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544218

Catalog No. PIMA544218

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: 53BP1
• Classification: Recombinant Monoclonal
• Concentration: 100 μg/mL
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
• Gene Accession No.: Q12888
• Gene Symbols: TP53BP1
• Immunogen: Synthetic peptide representing a region between residues 350 and 400 of human tumor protein p53 binding protein 1.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: BL-250-1H11
• Conjugate: Unconjugated
• Gene: TP53BP1
• Gene Alias: 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 7158
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov