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5HTR2C Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985044
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50-198-5044 100 μL
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Catalog No. 50-198-5044 Supplier Bioss Supplier No. BS2959R
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Description

Rabbit Polyclonal Antibody

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.

Specifications

Antigen 5HTR2C
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene HTR2C
Gene Accession No. P28335
Gene Alias 5ht1c; 5-HT1C; 5-HT-1C; 5HT-1C; 5-HT1c receptor; 5-HT2C; 5-HT-2C; 5HT2C Receptor; 5-HT2C receptor; 5-HT2cR; 5HTR2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; HGNC:5295; HTR1C; Htr2c; RP11-810O3.1; RP23-15B7.1; serotonin 1c receptor; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; Serotonin receptor 2C; SR1
Gene Symbols HTR2C
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human 5HTR2C.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3358
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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