6,7-Dihydroxycoumarin, 98+%

Description

CAS: 305-01-1 | C9H6O4 | 178.143 g/mol

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 305-01-1
• Molecular Formula: C9H6O4
• Molecular Weight (g/mol): 178.143
• MDL Number: MFCD00006874
• InChI Key: ILEDWLMCKZNDJK-UHFFFAOYSA-N
• Synonym: esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon
• PubChem CID: 5281416
• ChEBI: CHEBI:490095
• IUPAC Name: 6,7-dihydroxychromen-2-one
• SMILES: C1=CC(=O)OC2=CC(=C(C=C21)O)O

• Melting Point: ∼270°C (decomposition)
• Quantity: 1 g
• Beilstein: 152788
• Merck Index: 14,3697
• Solubility Information: Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol.
• Formula Weight: 178.15
• Percent Purity: ≥98%
• Chemical Name or Material: 6,7-Dihydroxycoumarin

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	206-161-5
RTECSNumber	GN6382500
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only