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  5. Tocris Bioscience™ 6,8-Bis(benzylthio)octanoic acid

Tocris Bioscience™ 6,8-Bis(benzylthio)octanoic acid
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Catalog No. 534850
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

PDH and KGDH inhibitor

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

Specifications

Chemical Name or Material 6,8-Bis[(phenylmethyl)thio]octanoic acid
CAS 95809-78-2
Quantity 50 mg
Target Dehydrogenase Inhibitors
Molecular Formula C22H28O2S2
Formula Weight 388.59
Purity >99%
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