6-Chlorouracil, 98+%, Thermo Scientific™

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

Solubility
Soluble in Ammonium Hydroxide

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Specifications

Chemical Identifiers

• CAS: 4270-27-3
• Molecular Formula: C4H3ClN2O2
• Molecular Weight (g/mol): 146.53
• MDL Number: MFCD00014595
• InChI Key: PKUFNWPSFCOSLU-UHFFFAOYSA-N
• Synonym: 6-chlorouracil, 6-chloropyrimidine-2,4 1h,3h-dione, 4-chlorouracil, 6-chloropyrimidine-2,4-diol, 6-chloro-2,4 1h,3h-pyrimidinedione, 6-chloro-2,4-dihydroxypyrimidine, 6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione, 6-chloro-2,4-pyrimidinediol, 6-chloro-1,3-dihydropyrimidine-2,4-dione, 4-chloro-2,6-dihydroxypyrimidine
• PubChem CID: 73272
• IUPAC Name: 6-chloro-1H-pyrimidine-2,4-dione
• SMILES: ClC1=CC(=O)NC(=O)N1

• Melting Point: ∽295°C (decomposition)
• Quantity: 1 g
• Beilstein: 120492
• Solubility Information: Soluble in Ammonium Hydroxide
• Formula Weight: 146.53
• Percent Purity: ≥98%
• Chemical Name or Material: 6-Chlorouracil

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	224-258-0
TSCA	No
Recommended Storage	Ambient temperatures

SDS