MilliporeSigma™ 60S RPL5, Rabbit, Unlabeled, Polyclonal,

Catalog No.	Quantity	Conjugate
ABE1439	100 μg	Unconjugated

Catalog No. ABE1439 Supplier MilliporeSigma™ Supplier No. ABE1439

Description

Rabbit Polyclonal Antibody

60S ribosomal protein L5 (UniProt P46777; also known as RPL5) is encoded by the RPL5 (also known as DBA6, MSTP030) gene (Gene ID 6125) in human. Ribosomal proteins (RPs) are normally involved in the assembly of the translational machinery-ribosomes essential for protein production. RPL5, RPL11 and the 5S rRNA comprise the 5S ribonucleoprotein particle (RNP), an essential subcomplex of the large ribosomal subunit. RPL5 binds the 5S rRNA, the 5S rRNA/RPL5 complex then localizes to the nucleolus, where it binds RPL11 and is integrated into the ribosome. In response to ribosomal stress (RS) or nucleolar stress, the L5/L11/5S pre-ribosomal complex is redirected to inhibit MDM2 E3 ligase activity, thereby promoting p53 stabilization and p53-dependent cell cycle arrest. RPL5 and RPL11 can also bind TAp73 N-terminal TA domain in an RS-independent manner and thereby prevent MDM2 association with TAp73 target gene promoters, resulting in enhanced TAp73 transcriptional activity and TAp73-dependent apoptosis induction and cell cycle arrest.

Specifications

• Antigen: 60S RPL5
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene: RPL5, DBA6, MSTP030
• Gene Accession No.: P46777
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to an internal sequence within the C-terminal half of human 60S RPL5.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics & Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_000960
• Test Specificity: This rabbit polyclonal antibody targets a highly conserved sequence within the C-terminal half of 60S RPL5 from multiple species.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.

For Research Use Only. Not for use in diagnostic procedures.