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Invitrogen™ 7-Ketocholesterol Monoclonal Antibody (3F7), PE

Catalog No. PIMA545800
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100 μg
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Catalog No. Quantity
PIMA545800 100 μg
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Catalog No. PIMA545800 Supplier Invitrogen™ Supplier No. MA545800
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Description

Mouse Monoclonal Antibody

A 1:1,000 dilution of MA5-45800 was sufficient for detection of 7-Ketocholesterol in 2 μg of 7-ketocholesterol conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody. Specific for 7-ketocholesterol modified proteins.

7-Ketocholesterol is a major oxidation product of cholesterol found in human atherosclerotic plaque and is more atherogenic than cholesterol in some animal studies. 7-Ketocholesterol can inhibit cholesterol 7alpha-hydroxylase, the rate-limiting step in bile acid biosynthesis, as well as strongly inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 7-Ketocholesterol
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3F7
Concentration 1 mg/mL
Conjugate PE
Formulation 2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Alias 7KC; 7-KC; 7KC-Modified KLH
Host Species Mouse
Immunogen Synthetic 7-Ketocholesterol conjugated to Keyhole Limpet Hemocyanin (KLH).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG3
Target Molecule Chemical
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Safety and Handling

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