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Tocris Bioscience™ 7rh
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Catalog No. 58605
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58-605 5 mg
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Catalog No. 58-605 Supplier Tocris Bioscience™ Supplier No. 5860/5
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Description

Potent and selective DDR1 inhibitor; orally bioavailable

7rh is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Specifications

Chemical Name or Material 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
CAS 1429617-90-2
Quantity 5 mg
Molecular Formula C30H29F3N6O
Purity 98%
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