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Tocris Bioscience™ A 1070722
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Catalog No. 443110
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Catalog No. Quantity
44-311-0 10 mg
44-315-0 50 mg
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Catalog No. 44-311-0 Supplier Tocris Bioscience™ Supplier No. 4431/10
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Description

Highly potent, selective GSK-3 inhibitor

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Chemical Identifiers

CAS 1384424-80-9
Molecular Formula C17H13F3N4O2

Specifications

Quantity 10 mg
Formula Weight 362.31
Purity >99%
Molecular Weight (g/mol) 362.312
Chemical Name or Material A 1070722

Safety and Handling

Recommended Storage Store at Room Temperature
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