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  5. Tocris Bioscience™ A 317491 sodium salt

Tocris Bioscience™ A 317491 sodium salt
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Catalog No. 64935
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25 mg
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64-935 5 mg
64-932-5 25 mg
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Catalog No. 64-935 Supplier Tocris Bioscience™ Supplier No. 6493/5
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Description

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

A 317491 sodium salt is a selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM). Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 > 5 μM). Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models. Antinociceptive.

Specifications

Chemical Name or Material 5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Quantity 5 mg
Target P2X Receptor Antagonists
Molecular Formula C33H25NO8Na2
Formula Weight 609.54
Product Type Antagonist
Purity 98%
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