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  5. Tocris Bioscience™ A 410099.1

Tocris Bioscience™ A 410099.1
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Catalog No. 647010
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Catalog No. Quantity
64-701-0 10 mg
64-705-0 50 mg
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Catalog No. 64-701-0 Supplier Tocris Bioscience™ Supplier No. 6470/10
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Description

High affinity XIAP antagonist

A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

Specifications

Quantity 10 mg
Molecular Formula C27H40N4O3.HCl
Formula Weight 505.09
Product Type Antagonist
Purity 98%
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