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A 83-01, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
909910-43-6
C25H19N5S
421.522
HIJMSZGHKQPPJS-UHFFFAOYSA-N
alk5 inhibitor iv,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl-1h-pyrazole-1-carbothioamide,tgf-beta inhibitor a-83-01,1h-pyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl,transforming growth factor-beta type i receptor kinase inhibitor iv,3-6-methylpyridin-2-yl-4-4-quinolyl-1-phenylthiocarbamoyl-1h-pyrazole,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl pyrazole-1-carbothioamide,tgfss inhibitor a-83-01,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl-1h-pyrazole-1-carbothioamide
16218924
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
This item is not returnable. View return policy
909910-43-6
C25H19N5S
421.522
HIJMSZGHKQPPJS-UHFFFAOYSA-N
alk5 inhibitor iv,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl-1h-pyrazole-1-carbothioamide,tgf-beta inhibitor a-83-01,1h-pyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl,transforming growth factor-beta type i receptor kinase inhibitor iv,3-6-methylpyridin-2-yl-4-4-quinolyl-1-phenylthiocarbamoyl-1h-pyrazole,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl pyrazole-1-carbothioamide,tgfss inhibitor a-83-01,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl-1h-pyrazole-1-carbothioamide
16218924
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.

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Quantity 10mg
Formula Weight 421.52
Percent Purity >98%
Chemical Name or Material A 83-01

Recommended Storage : Store at -20°C