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Tocris Bioscience™ A 971432
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Catalog No. 576610
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57-661-0 10 mg
57-665-0 50 mg
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Description

Potent and selective S1P5 agonist

A 971432 is a potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Specifications

Chemical Name or Material 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
CAS 1240308-45-5
Quantity 10 mg
Target Sphingosine-1-phosphate Receptor Agonists
Molecular Formula C18H17Cl2NO3
Formula Weight 366.24
Purity >99%
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