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Tocris Bioscience™ (+/-)-a-Lipoamide, Liquid-Liquid Phase Separated

Catalog No. 7044100
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Quantity:
100 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Liquid-liquid phase separated condensate modifier; reduces stress granule formation

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Specifications

Chemical Name or Material 1,2-Dithiolane-3-pentanoic acid
CAS 1077-28-7
Quantity 100 mg
Molecular Formula C8H14O2S2
Purity 98%
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