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Tocris Bioscience™ (+/-)-a-Lipoamide, Phase Separated

Catalog No. 7045100
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100 mg
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70-451-00 100 mg
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Description

Phase-separated condensate modifier; orally bioavailable

(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Specifications

Chemical Name or Material 1,2-Dithiolane-3-pentanamide
CAS 940-69-2
Quantity 100 mg
Molecular Formula C8H15NOS2
Purity 98%
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