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Invitrogen™ A2M Polyclonal Antibody
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Catalog No. PIPA582009
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100 μL
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PIPA582009 100 μL
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Catalog No. PIPA582009 Supplier Invitrogen™ Supplier No. PA582009
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SVLLMKPDAE LSASSVYNLL PEKDLTGFPG PLNDQDDEDC INRHNVYING ITYTPVSSTN EKDMYSFLED MGLKAFTNSK IRKPKMCPQL QQYEMHGPEG LRVGFYESDV MGRGHARLVH VEEPHTETVR KYFPETWIWD LVVVNS Highest antigen sequence indentity to the following orthologs: Mouse - 53%, Rat - 52%.

Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregnancy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer's disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen A2M
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene A2M
Gene Accession No. P01023
Gene Alias A2M; A2m1; A2maa; A2MAC1; A2MD; A2mp; Alpha 2 M; Alpha-2-M; Alpha-2-M (A2M); alpha-2-macroglobulin; Alpha-2-macroglobulin-P; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; LOC100061656; Mam; S863 7; S863-7
Gene Symbols A2M
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human A2M. Recombinant protein control fragment (Product #RP-100469).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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