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AAK1 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31

Specifications

Antigen AAK1
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-156-1884
Encompass_Preferred
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Bethyl Laboratories, Inc
A302145AT
20 μL
Each of 1 for $151.31
Only null left
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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine and Pig

AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.
Specifications

Specifications

AAK1
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
AP2-associated protein kinase 1; Adaptor-associated kinase 1; AAK1; KIAA1048
AAK1
IgG
Antigen affinity chromatography
Antibody
Western Blot
Unconjugated
Rabbit
Human
Q2M2I8
22848
Between 310 and 360
Primary
4° C
AAK1
Videos
SDS
Documents

Documents

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