Invitrogen™ ABCA1 Polyclonal Antibody, DyLight™ 488

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522908

Catalog No. PIPA522908

Description

ABCA1 Polyclonal Antibody for Western Blot, ICC/IF, IHC (F), IHC (P), Flow, IP, ChIP, ELISA, GS, Neu, ISH

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Specifications

• Antigen: ABCA1
• Classification: Polyclonal
• Conjugate: DyLight 488
• Gene: Abca1
• Gene Alias: ABC 1; ABC 1 antibody; ABC Transporter 1; Abc1; ABC-1; ABC1 antibody; Abca1; ATP binding cassette subfamily A member 1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, subfamily A (ABC1), member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette, sub-family A member 1; CERP; CERP antibody; Cholesterol efflux regulatory protein; HDLDT1; membrane-bound; phospholipid-transporting ATPase ABCA1; phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; TGD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100054241, 100152112, 100356765, 100761226, 11303, 19, 313210, 373945, 481651
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: ChIP Assay, ELISA, Flow Cytometry, Gel Shift, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In Situ Hybridization (ISH), Neutralization, Western Blot, Immunocytochemistry
• Concentration: 1.00 mg/mL
• Formulation: 50mM sodium borate with 0.05% sodium azide
• Gene Accession No.: O95477, P41233
• Gene Symbols: Abca1
• Immunogen: Partial peptide sequence (within residues 1100-1300) of human ABCA1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Rabbit, Monkey, Hamster, Pig, Horse, Chicken, Mustelid
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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