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Invitrogen™ ABCA4 Monoclonal Antibody (3F4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA533095

Catalog No. PIMA533095


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Description

Description

Excitation: 405 nm; Emission: 645 nm; Laser: Blue Laser.

ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ABCA4
Monoclonal
∼1 mg/mL
10mM HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
O35600, P78363
ABCA4, abca4.L
Partially purified bovine 220-kDa disc rim protein.
100 μL
Primary
Human, Mouse, Bovine, Frog
Antibody
IgG1
Immunohistochemistry, Western Blot
3F4
Unconjugated
ABCA4
ABC transporter; ABC10; abca4; abca4.L; Abcr; ARMD2; ATP binding cassette subfamily A member 4; ATP binding cassette subfamily A member 4 L homeolog; ATP binding cassette transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, subfamily A (ABC1), member 4; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding cassette, sub-family A, member 4; ATP-binding transporter, retina-specific; AW050280; CORD3; D430003I15Rik; FFM; photoreceptor rim protein; retinal ABCA4 transporter; retinal-specific ATP-binding cassette transporter; Retinal-specific phospholipid-transporting ATPase ABCA4; retina-specific ABC transporter; RIM ABC transporter; RIM protein; RMP; RP19; Stargardt disease protein; STGD; STGD1; XELAEV_180233141mg
Mouse
Protein G
RUO
11304, 24, 281584, 497268
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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