Invitrogen™ ABCA4 Polyclonal Antibody

Catalog No.	Quantity
PIPA5142378	100 μg

Catalog No. PIPA5142378 Supplier Invitrogen™ Supplier No. PA5142378

Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.

Specifications

• Antigen: ABCA4
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene: ABCA4
• Gene Accession No.: O35600, P78363
• Gene Alias: ABC transporter; ABC10; abca4; abca4.L; Abcr; ARMD2; ATP binding cassette subfamily A member 4; ATP binding cassette subfamily A member 4 L homeolog; ATP binding cassette transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, subfamily A (ABC1), member 4; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding cassette, sub-family A, member 4; ATP-binding transporter, retina-specific; AW050280; CORD3; D430003I15Rik; FFM; photoreceptor rim protein; retinal ABCA4 transporter; retinal-specific ATP-binding cassette transporter; Retinal-specific phospholipid-transporting ATPase ABCA4; retina-specific ABC transporter; RIM ABC transporter; RIM protein; RMP; RP19; Stargardt disease protein; STGD; STGD1; XELAEV_180233141mg
• Gene Symbols: ABCA4
• Host Species: Goat
• Immunogen: Peptide with sequence C-KQQTESHDLPLHPR.
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11304, 24
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG