Invitrogen™ ABCA5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537131

Catalog No. PIPA537131

Description

This antibody detects endogenous protein at a molecular weight of 186 kDa. Purity is >95% by SDS-PAGE.

ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes. Ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver and placenta, ABCA5 is a multi-pass membrane protein that contains two ABC transporter domains and exists as three alternatively spliced isoforms. ABCA5 exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site. ABCA5 is the first of five ABC1 family members that maps to human chromosome 17q24. ABCA5 is linked to lysosomal diseases and may play a role in tumor development and cardiomyocyte and follicular cell activities. ABCA5 might also be a specific urine marker for diagnosis of patients with high-grade prostatic intraepithelial neoplasia (HGPIN).

Specifications

• Antigen: ABCA5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCA5
• Gene Alias: ABC13; Abca5; ATP binding cassette subfamily A member 5; ATP-binding cassette A5; ATP-binding cassette sub-family A member 5; ATP-binding cassette transporter sub-family A member 5; ATP-binding cassette, subfamily A (ABC1), member 5; ATP-binding cassette, sub-family A (ABC1), member 5; ATP-binding cassette, sub-family A , member 5; B930033A02Rik; DKFZp451F117; DKFZp779N2435; EST90625; FLJ16381; Kiaa1888; mKIAA1888
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217265, 23461, 286970
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8CF82, Q8K448, Q8WWZ7
• Gene Symbols: ABCA5
• Immunogen: A synthetic peptide corresponding to residues in human ABCA5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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