ABCB1 Mouse anti-Human, Clone: OTI2H2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809803

Catalog No. 50-166-9725

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Specifications

• Antigen: ABCB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ABCB1
• Gene Alias: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5243
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2H2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P08183
• Gene Symbols: ABCB1
• Immunogen: Human recombit protein fragment corresponding to amino acids 995-1280 of human ABCB1 produced in SF9 cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1