Invitrogen™ ABCB4 Polyclonal Antibody

Catalog No.	Quantity
PIPA578692	100 μg

Catalog No. PIPA578692 Supplier Invitrogen™ Supplier No. PA578692

Description

Rabbit Polyclonal Antibody

Human Apolipoprotein A I shares 64% and 61.7% amino acid (aa) sequence identity with mouse and rat Apolipoprotein A I, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HepG2 whole cell, rat liver tissue, rat RH35 whole cell, mouse liver tissue. IHC: human liver cancer tissue. Flow: HepG2 cell.

The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Specifications

• Antigen: ABCB4
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: ABCB4
• Gene Accession No.: P21439, P21440, Q08201
• Gene Alias: ABC20; ABC21; ABCB4; ATP binding cassette subfamily B member 4; ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2; ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette sub-family B member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette, subfamily B, member 4; CD243; CLCS; GBD1; GP170; ICP3; MDR1; MDR2; mdr-2; MDR2/3; MDR3; MGC163296; Multidrug resistance protein 2; multidrug resistance protein 3; multiple drug resistance 3; P glycoprotein 2; P glycoprotein 3/multiple drug resistance 3; PFIC-3; P-glycoprotein 2; P-glycoprotein 3; P-glycoprotein 3/ multidrug resistance 2; P-glycoprotein-3/multiple drug resistance-3; P-GP; Pgp3; PGY1; Pgy2; Pgy-2; Pgy3; Phosphatidylcholine translocator ABCB4
• Gene Symbols: ABCB4
• Host Species: Rabbit
• Immunogen: E.coli-derived human ABCB4 recombinant protein (Position: A601-A720).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18670, 24891, 5244
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov