Invitrogen™ ABCB4 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142388

Catalog No. PIPA5142388

Description

Additional Information: This antibody is expected to recognize all three reported isoforms (NP_000434.1; NP_061337.1; NP_061338.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Specifications

• Antigen: ABCB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCB4
• Gene Alias: ABC20; ABC21; ABCB4; ATP binding cassette subfamily B member 4; ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2; ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette sub-family B member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette, subfamily B, member 4; CD243; CLCS; GBD1; GP170; ICP3; MDR1; MDR2; mdr-2; MDR2/3; MDR3; MGC163296; Multidrug resistance protein 2; multidrug resistance protein 3; multiple drug resistance 3; P glycoprotein 2; P glycoprotein 3/multiple drug resistance 3; PFIC-3; P-glycoprotein 2; P-glycoprotein 3; P-glycoprotein 3/ multidrug resistance 2; P-glycoprotein-3/multiple drug resistance-3; P-GP; Pgp3; PGY1; Pgy2; Pgy-2; Pgy3; Phosphatidylcholine translocator ABCB4
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 5244
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P21439
• Gene Symbols: ABCB4
• Immunogen: Peptide with sequence DLEAAKNGTAWRP-C (aa 2-14).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG