ABCC2 Rabbit anti-Human, Polyclonal, liquid, OriGene

Rabbit Polyclonal Antibody

Supplier:  OriGene TA890096

Catalog No. 50-168-4782

Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Specifications

• Antigen: ABCC2
• Classification: Polyclonal
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q92887
• Gene Symbols: ABCC2
• Immunogen: Recombit protein of human ABCC2
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: ABCC2
• Gene Alias: ABC30, CMOAT, DJS, MRP2, cMRP
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1244
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid