Invitrogen™ ABCD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530139

Catalog No. PIPA530139

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Human (99%), Mouse (94%), Rat (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.

Specifications

• Antigen: ABCD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCD4
• Gene Alias: 69 kDa peroxisomal ABC-transporter; ABC41; ABCD4; ATP binding cassette subfamily D member 4; ATP-binding cassette sub-family D member 4; ATP-binding cassette, subfamily D (ALD), member 4; ATP-binding cassette, sub-family D (ALD), member 4; ATP-binding cassette, sub-family D, member 4; EST352188; MAHCJ; P69r; P70R; P79R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related; PMP69; PMP70-related protein; Pxmp1l; PXMP1-L
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5826
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.79 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O14678
• Gene Symbols: ABCD4
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 38 and 296 of Human ABCD4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG