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Invitrogen™ ABCD4 Polyclonal Antibody
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Catalog No. PIPA5109352
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100 μL
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PIPA5109352 100 μL
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Catalog No. PIPA5109352 Supplier Invitrogen™ Supplier No. PA5109352
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DQFTCNLLYV SWRKDLTEHL HRLYFRGRAY YTLNVLRDDI DNPDQRISQD VERFCRQLSS MASKLIISPF TLVYYTYQCF QSTGWLGPVS IFGYFILGTV VNKTLMGPIV MKLVHQEKLE GDFRFKHMQI RVNAEPAAFY RAGHVEHMRT DRRLQRLLQT QRELMSKELW LYIGINTFDY L.

The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ABCD4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.41 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ABCD4
Gene Accession No. O14678
Gene Alias 69 kDa peroxisomal ABC-transporter; ABC41; ABCD4; ATP binding cassette subfamily D member 4; ATP-binding cassette sub-family D member 4; ATP-binding cassette, subfamily D (ALD), member 4; ATP-binding cassette, sub-family D (ALD), member 4; ATP-binding cassette, sub-family D, member 4; EST352188; MAHCJ; P69r; P70R; P79R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related; PMP69; PMP70-related protein; Pxmp1l; PXMP1-L
Gene Symbols ABCD4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5826
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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