Invitrogen™ ABCG4 Polyclonal Antibody

Catalog No.	Quantity
PIPA589928	100 μL

Catalog No. PIPA589928 Supplier Invitrogen™ Supplier No. PA589928

Description

Rabbit Polyclonal Antibody

Immunogen sequence: KLYILSQGQC IFKGVVTNLI PYLKGLGLHC PTYHNPADFI IEVASGEYGD LNPMLFRAVQ NGLCAMAEKK SSPEKNEVPA PCPPCPPEVD PIESHTFATS T; Positive Samples: U-87MG, A-549, U937, Mouse brain, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein.

The ABCG4 gene encodes the ATP-binding cassette sub-family G member 4, a protein that is part of the ABC transporter family involved in the transport of various molecules across cellular membranes. ABC transporters play essential roles in lipid transport, drug resistance, and the maintenance of cellular homeostasis. ABCG4, specifically, is known to be involved in the transport of cholesterol and other lipids, influencing lipid homeostasis and potentially impacting processes such as cholesterol efflux and cellular lipid balance. This protein is expressed in specific tissues, including the brain and retina, indicating its role in neuronal lipid metabolism and health. While its exact physiological functions are still being elucidated, alterations in ABCG4 expression or function may be implicated in lipid-related disorders and neurodegenerative diseases, where lipid metabolism plays a crucial part. Research into ABCG4 focuses on understanding its transport mechanisms and potential contributions to pathological states, aiming to develop targeted therapies that address imbalances in lipid and cholesterol metabolism.

Specifications

• Antigen: ABCG4
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Abcg4
• Gene Accession No.: Q9H172
• Gene Alias: 6430517O04Rik; ABCG4; ATP binding cassette subfamily G member 4; ATP-binding cassette sub-family G member 4; ATP-binding cassette, subfamily G (WHITE), member 4; ATP-binding cassette, sub-family G (WHITE), member 4; putative ABC transporter; WHITE2
• Gene Symbols: Abcg4
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human ABCG4 (NP_0714522).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 192663, 300664, 64137
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG