Invitrogen™ ABCG8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554024

Catalog No. PIPA554024

Description

Immunogen sequence: HMVQYFTAIG YPCPRYSNPA DFYVDLTSID RRSREQELAT REKAQSLAAL FLEKVRDLDD FLWKAETKDL DEDTCVESSV TPLDTNCLPS PTKMPGAVQQ FTTLIRRQIS NDFRDLP Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 74%.

ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.

Specifications

• Antigen: ABCG8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Abcg8
• Gene Alias: 1300003C16Rik; ABCG8; AI114946; ATP binding cassette subfamily G member 8; ATP-binding cassette sub-family G member 8; ATP-binding cassette, subfamily G (WHITE), member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G, member 8; GBD4; MGC142217; sterolin 2; Sterolin2; sterolin-2; STSL
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64241
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H221
• Gene Symbols: Abcg8
• Immunogen: Recombinant protein corresponding to Human ABCG8. Recombinant protein control fragment (Product #RP-91216).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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