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Invitrogen™ Abciximab Chimeric Recombinant Rabbit Monoclonal Antibody (7E3 (Abciximab))
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Catalog No. PIMA547866
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200 μg
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PIMA547866 200 μg
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Catalog No. PIMA547866 Supplier Invitrogen™ Supplier No. MA547866
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Recognises human CD41.

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (alpha-v-beta-3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GpiIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GpiIb/IIIa. By binding to the vitronectin receptor (also known as the alpha-v-beta-3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Abciximab Chimeric
Applications Flow Cytometry, Inhibition Assays
Classification Recombinant Monoclonal
Clone 7E3 (Abciximab)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias c7E3
Host Species Rabbit
Immunogen CD41 is the integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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