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Invitrogen™ Abciximab Recombinant Human Monoclonal Antibody (7E3 (Abciximab))
Human Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA547865
Description
Specificity: Recognises human CD41.
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (alpha-v-beta-3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GpiIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GpiIb/IIIa. By binding to the vitronectin receptor (also known as the alpha-v-beta-3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
Specifications
Abciximab | |
Recombinant Monoclonal | |
1 mg/mL | |
PBS with 0.02% ProClin 300 | |
Human | |
Protein A | |
RUO | |
Human | |
Antibody | |
IgG1 κ |
Flow Cytometry, Inhibition Assays | |
7E3 (Abciximab) | |
Unconjugated | |
c7E3 | |
CD41 is the integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3. | |
200 μg | |
Primary | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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