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Invitrogen™ ABH1 Recombinant Rabbit Monoclonal Antibody (5K4W5)
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Catalog No. PIMA535781
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100 μL
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PIMA535781 100 μL
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Catalog No. PIMA535781 Supplier Invitrogen™ Supplier No. MA535781
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MGKMAAAVGS VATLATEPGE DAFRKLFRFY RQSRPGTADL EGVIDFSAAH AARGKGPGAQ KVIKSQLNVS SVSEQNAYRA GLQPVSKWQA YGLKGYPGFI.

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ABH1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 5K4W5
Concentration 1.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ALKBH1
Gene Accession No. P0CB42, Q13686
Gene Alias 2700073G19Rik; Abh; ABH1; alkB; alkB homolog 1, histone H2A dioxygenase; alkB, alkylation repair homolog 1; alkB, alkylation repair homolog 1 (E. coli); ALKBH; Alkbh1; Alkylated DNA repair protein alkB homolog 1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA demethylase ALKBH1; DNA lyase ABH1; DNA N6-methyl adenine demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA oxidative demethylase ALKBH1; hABH; mRNA N(3)-methylcytidine demethylase; Nucleic acid dioxygenase ALKBH1; tRNA N1-methyl adenine demethylase
Gene Symbols ALKBH1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ALKBH1 (Q13686).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211064, 362766, 8846
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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